Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

Rapamycin, an inhibitor of mechanistic target of rapamycin complex 1 (mTORC1), extends the lifespans of yeast, flies, and mice. Calorie restriction, which increases lifespan and insulin sensitivity, is proposed to function by inhibition of mTORC1, yet paradoxically, chronic administration of rapamyc...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Lamming, Dudley W., Ye, Lan, Katajisto, Pekka, Goncalves, Marcus D., Saitoh, Maki, Stevens, Deanna M., Davis, James G., Salmon, Adam B., Richardson, Arlan, Ahima, Rexford S., Guertin, David A., Sabatini, David M., Baur, Joseph A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324089/
https://ncbi.nlm.nih.gov/pubmed/22461615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1215135
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы