Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan

Rapamycin, an inhibitor of the mechanistic target of rapamycin (mTOR), robustly extends the lifespan of model organisms including mice. We recently found that chronic treatment with rapamycin not only inhibits mTOR complex 1 (mTORC1), the canonical target of rapamycin, but also inhibits mTOR complex...

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Bibliografiske detaljer
Main Authors:	Lamming, Dudley W, Mihaylova, Maria M, Katajisto, Pekka, Baar, Emma L, Yilmaz, Omer H, Hutchins, Amanda, Gultekin, Yetis, Gaither, Rachel, Sabatini, David M
Format:	Artigo
Sprog:	Inglês
Udgivet:	BlackWell Publishing Ltd 2014
Fag:	Original Articles
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4172536/ https://ncbi.nlm.nih.gov/pubmed/25059582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12256
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Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan

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