Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan

Rapamycin, an inhibitor of the mechanistic target of rapamycin (mTOR), robustly extends the lifespan of model organisms including mice. We recently found that chronic treatment with rapamycin not only inhibits mTOR complex 1 (mTORC1), the canonical target of rapamycin, but also inhibits mTOR complex...

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Bibliografiska uppgifter
Huvudupphovsmän: Lamming, Dudley W, Mihaylova, Maria M, Katajisto, Pekka, Baar, Emma L, Yilmaz, Omer H, Hutchins, Amanda, Gultekin, Yetis, Gaither, Rachel, Sabatini, David M
Materialtyp: Artigo
Språk:Inglês
Publicerad: BlackWell Publishing Ltd 2014
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Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172536/
https://ncbi.nlm.nih.gov/pubmed/25059582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12256
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