Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan

Rapamycin, an inhibitor of the mechanistic target of rapamycin (mTOR), robustly extends the lifespan of model organisms including mice. We recently found that chronic treatment with rapamycin not only inhibits mTOR complex 1 (mTORC1), the canonical target of rapamycin, but also inhibits mTOR complex...

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Bibliografische gegevens
Hoofdauteurs: Lamming, Dudley W, Mihaylova, Maria M, Katajisto, Pekka, Baar, Emma L, Yilmaz, Omer H, Hutchins, Amanda, Gultekin, Yetis, Gaither, Rachel, Sabatini, David M
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BlackWell Publishing Ltd 2014
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Original Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172536/
https://ncbi.nlm.nih.gov/pubmed/25059582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12256
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