Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan

Rapamycin, an inhibitor of the mechanistic target of rapamycin (mTOR), robustly extends the lifespan of model organisms including mice. We recently found that chronic treatment with rapamycin not only inhibits mTOR complex 1 (mTORC1), the canonical target of rapamycin, but also inhibits mTOR complex...

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Detaylı Bibliyografya
Asıl Yazarlar: Lamming, Dudley W, Mihaylova, Maria M, Katajisto, Pekka, Baar, Emma L, Yilmaz, Omer H, Hutchins, Amanda, Gultekin, Yetis, Gaither, Rachel, Sabatini, David M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BlackWell Publishing Ltd 2014
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172536/
https://ncbi.nlm.nih.gov/pubmed/25059582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12256
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