Calorie restriction-induced insulin sensitivity is mediated by adipose mTORC2 and not required for lifespan extension

Calorie restriction (CR) extends the healthspan and lifespan of diverse species. In mammals, a broadly conserved metabolic effect of CR is improved insulin sensitivity, which may mediate the beneficial effects of a CR diet. This model has been challenged by the identification of interventions that e...

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Udgivet i:Cell Rep
Main Authors: Yu, Deyang, Tomasiewicz, Jay L., Yang, Shany E., Miller, Blake R., Wakai, Matthew H., Sherman, Dawn S., Cummings, Nicole E., Baar, Emma L., Brinkman, Jacqueline A., Syed, Faizan A., Lamming, Dudley W.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820997/
https://ncbi.nlm.nih.gov/pubmed/31577953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.08.084
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