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Calorie restriction-induced insulin sensitivity is mediated by adipose mTORC2 and not required for lifespan extension
Calorie restriction (CR) extends the healthspan and lifespan of diverse species. In mammals, a broadly conserved metabolic effect of CR is improved insulin sensitivity, which may mediate the beneficial effects of a CR diet. This model has been challenged by the identification of interventions that e...
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| Publicat a: | Cell Rep |
|---|---|
| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6820997/ https://ncbi.nlm.nih.gov/pubmed/31577953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.08.084 |
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