Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging

Inhibition of mTOR (mechanistic Target Of Rapamycin) signaling by rapamycin promotes healthspan and longevity more strongly in females than males, perhaps because inhibition of hepatic mTORC2 (mTOR Complex 2) specifically reduces the lifespan of males. Here, we demonstrate using gonadectomy that the...

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Udgivet i:eLife
Main Authors: Arriola Apelo, Sebastian I, Lin, Amy, Brinkman, Jacqueline A, Meyer, Emma, Morrison, Mark, Tomasiewicz, Jay L, Pumper, Cassidy P, Baar, Emma L, Richardson, Nicole E, Alotaibi, Mohammed, Lamming, Dudley W
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2020
Fag:
Genetics and Genomics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7386906/
https://ncbi.nlm.nih.gov/pubmed/32720643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56177
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