Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging

Inhibition of mTOR (mechanistic Target Of Rapamycin) signaling by rapamycin promotes healthspan and longevity more strongly in females than males, perhaps because inhibition of hepatic mTORC2 (mTOR Complex 2) specifically reduces the lifespan of males. Here, we demonstrate using gonadectomy that the...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:eLife
Autors principals: Arriola Apelo, Sebastian I, Lin, Amy, Brinkman, Jacqueline A, Meyer, Emma, Morrison, Mark, Tomasiewicz, Jay L, Pumper, Cassidy P, Baar, Emma L, Richardson, Nicole E, Alotaibi, Mohammed, Lamming, Dudley W
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2020
Matèries:
Genetics and Genomics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7386906/
https://ncbi.nlm.nih.gov/pubmed/32720643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56177
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars