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Rapalogs and mTOR inhibitors as anti-aging therapeutics

Rapamycin, an inhibitor of mechanistic target of rapamycin (mTOR), has the strongest experimental support to date as a potential anti-aging therapeutic in mammals. Unlike many other compounds that have been claimed to influence longevity, rapamycin has been repeatedly tested in long-lived, genetical...

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Autori principali: Lamming, Dudley W., Ye, Lan, Sabatini, David M., Baur, Joseph A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582126/
https://ncbi.nlm.nih.gov/pubmed/23454761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64099
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