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Sex‐ and tissue‐specific changes in mTOR signaling with age in C57BL/6J mice

Inhibition of the mTOR (mechanistic Target Of Rapamycin) signaling pathway robustly extends the lifespan of model organisms including mice. The precise molecular mechanisms and physiological effects that underlie the beneficial effects of rapamycin are an exciting area of research. Surprisingly, whi...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Baar, Emma L., Carbajal, Kathryn A., Ong, Irene M., Lamming, Dudley W.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717274/
https://ncbi.nlm.nih.gov/pubmed/26695882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12425
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