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A Kinetic Alignment of Orthologous Inosine-5′-monophosphate Dehydrogenases
[Image: see text] IMP dehydrogenase (IMPDH) catalyzes two very different chemical transformations, a dehydrogenase reaction and a hydrolysis reaction. The enzyme toggles between the open conformation required for the dehydrogenase reaction and the closed conformation of the hydrolase reaction by mov...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2646883/ https://ncbi.nlm.nih.gov/pubmed/18642884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800674a |
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