Triazole inhibitors of Cryptosporidium parvum inosine 5′-monophosphate dehydrogenase

Cryptosporidium parvum is an important human pathogen and potential bioterrorism agent. This protozoan parasite cannot salvage guanine or guanosine and therefore relies on inosine 5′-monophosphate dehydrogenase (IMPDH) for biosynthesis of guanine nucleotides and hence for survival. Since C. parvum I...

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Main Authors: Maurya, Sushil K., Gollapalli, Deviprasad R., Kirubakaran, Sivapriya, Zhang, Minjia, Johnson, Corey R., Benjamin, Nicole N., Hedstrom, Lizbeth, Cuny, Gregory D.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810100/
https://ncbi.nlm.nih.gov/pubmed/19624136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900410u
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