Optimization of benzoxazole-based inhibitors of Cryptosporidium parvum inosine 5′-monophosphate dehydrogenase

Cryptosporidium parvum is an enteric protozoan parasite that has emerged as a major cause of diarrhea, malnutrition and gastroenteritis as well as posing a potential bioterrorism threat. C. parvum synthesizes guanine nucleotides from host adenosine in a streamlined pathway that relies on inosine 5′-...

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Bibliografiske detaljer
Main Authors: Gorla, Suresh Kumar, Kavitha, Mandapati, Zhang, Minjia, Chin, James En Wai, Liu, Xiaoping, Striepen, Boris, Makowska-Grzyska, Magdalena, Kim, Youngchang, Joachimiak, Andrzej, Hedstrom, Lizbeth, Cuny, Gregory D.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3756936/
https://ncbi.nlm.nih.gov/pubmed/23668331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400241j
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