Repurposing Cryptosporidium Inosine 5′-Monophosphate Dehydrogenase Inhibitors as Potential Antibacterial Agents

[Image: see text] Inosine 5′-monophosphate dehydrogenase (IMPDH) catalyzes the pivotal step in guanine nucleotide biosynthesis. IMPDH is a target for immunosuppressive, antiviral, and anticancer drugs, but, as of yet, has not been exploited for antimicrobial therapy. We have previously reported pote...

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Main Authors: Mandapati, Kavitha, Gorla, Suresh Kumar, House, Amanda L., McKenney, Elizabeth S., Zhang, Minjia, Rao, Suraj Nagendra, Gollapalli, Deviprasad R., Mann, Barbara J., Goldberg, Joanna B., Cuny, Gregory D., Glomski, Ian J., Hedstrom, Lizbeth
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2014
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137380/
https://ncbi.nlm.nih.gov/pubmed/25147601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500203p
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