Repurposing Cryptosporidium Inosine 5′-Monophosphate Dehydrogenase Inhibitors as Potential Antibacterial Agents

[Image: see text] Inosine 5′-monophosphate dehydrogenase (IMPDH) catalyzes the pivotal step in guanine nucleotide biosynthesis. IMPDH is a target for immunosuppressive, antiviral, and anticancer drugs, but, as of yet, has not been exploited for antimicrobial therapy. We have previously reported pote...

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Detalhes bibliográficos
Main Authors: Mandapati, Kavitha, Gorla, Suresh Kumar, House, Amanda L., McKenney, Elizabeth S., Zhang, Minjia, Rao, Suraj Nagendra, Gollapalli, Deviprasad R., Mann, Barbara J., Goldberg, Joanna B., Cuny, Gregory D., Glomski, Ian J., Hedstrom, Lizbeth
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137380/
https://ncbi.nlm.nih.gov/pubmed/25147601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500203p
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