Phthalazinone Inhibitors of Inosine-5′-Monophosphate Dehydrogenase from Cryptosporidium parvum

Cryptosporidium parvum (Cp) is a potential biowarfare agent and major cause of diarrhea and malnutrition. This protozoan parasite relies on inosine 5′-monophosphate dehydrogenase (IMPDH) for the production of guanine nucleotides. A CpIMPDH-selective N-aryl-3,4-dihydro-3-methyl-4-oxo-1-phthalazineace...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Johnson, Corey R., Gorla, Suresh Kumar, Kavitha, Mandapati, Zhang, Minjia, Liu, Xiaoping, Striepen, Boris, Mead, Jan R., Cuny, Gregory D., Hedstrom, Lizbeth
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557747/
https://ncbi.nlm.nih.gov/pubmed/23324406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.12.037
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