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Phthalazinone Inhibitors of Inosine-5′-Monophosphate Dehydrogenase from Cryptosporidium parvum
Cryptosporidium parvum (Cp) is a potential biowarfare agent and major cause of diarrhea and malnutrition. This protozoan parasite relies on inosine 5′-monophosphate dehydrogenase (IMPDH) for the production of guanine nucleotides. A CpIMPDH-selective N-aryl-3,4-dihydro-3-methyl-4-oxo-1-phthalazineace...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3557747/ https://ncbi.nlm.nih.gov/pubmed/23324406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.12.037 |
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