IMP Dehydrogenase: Structure, Mechanism and Inhibition

Por Hedstrom, Lizbeth
Publicado em 2009

The dynamic determinants of reaction specificity in the IMPDH/GMPR family of (β/α)(8) barrel enzymes

Por Hedstrom, Lizbeth
Publicado em 2012

Cryptosporidium: a first step toward tractability

Por Hedstrom, Lizbeth
Publicado no Trends Parasitol (2015)

The bare essentials of antibiotic target validation

Por Hedstrom, Lizbeth
Publicado no ACS Infect Dis (2016)

Autosomal dominant retinitis pigmentosa mutations in inosine 5′-monophosphate dehydrogenase type I disrupt nucleic acid binding

Por Mortimer, Sarah E., Hedstrom, Lizbeth
Publicado em 2005

Mushroom Tyrosinase Oxidizes Tyrosine-rich Sequences, Allowing Selective Protein Functionalization

Por Long, Marcus J. C., Hedstrom, Lizbeth
Publicado em 2012

Short-lived protease–serpin complexes: Partial disruption of the rat trypsin active site

Por Liu, Lu, Mushero, Nicole, Hedstrom, Lizbeth, Gershenson, Anne
Publicado em 2007

The Cys319 loop modulates the transition between dehydrogenase and hydrolase conformations in IMP dehydrogenase

Por Josephine, Helen R., Ravichandran, Kanchana R., Hedstrom, Lizbeth
Publicado em 2010

Specific biotinylation of IMP dehydrogenase

Por Hoefler, B. Christopher, Gollapalli, Deviprasad R., Hedstrom, Lizbeth
Publicado em 2011

Kinetically Controlled Drug Resistance: HOW PENICILLIUM BREVICOMPACTUM SURVIVES MYCOPHENOLIC ACID

Por Sun, Xin E., Hansen, Bjarne Gram, Hedstrom, Lizbeth
Publicado em 2011

Inhibitor Mediated Protein Degradation

Por Long, Marcus J. C., Gollapalli, Deviprasad R., Hedstrom, Lizbeth
Publicado em 2012

A structural determinant of mycophenolic acid resistance in eukaryotic inosine 5′‐monophosphate dehydrogenases

Por Freedman, Rebecca, Yu, Runhan, Sarkis, Alexander W., Hedstrom, Lizbeth
Publicado no Protein Sci (2019)

A Kinetic Alignment of Orthologous Inosine-5′-monophosphate Dehydrogenases

Por Riera, Thomas V., Wang, Wen, Josephine, Helen R., Hedstrom, Lizbeth
Publicado em 2008

Using supramolecular hydrogel to discover the interactions between proteins and molecular nanofibers of small molecules

Por Gao, Yuan, Long, Marcus, Shi, Junfeng, Hedstrom, Lizbeth, Xu, Bing
Publicado em 2012

The antibiotic potential of prokaryotic IMP dehydrogenase inhibitors

Por Hedstrom, Lizbeth, Liechti, George, Goldberg, Joanna B., Gollapalli, Deviprasad R.
Publicado no Curr Med Chem (2011)

Inhibition of IMPDH from Bacillus anthracis: Mechanism revealed by pre-steady state kinetics

Por Wei, Yang, Kuzmič, Petr, Yu, Runhan, Modi, Gyan, Hedstrom, Lizbeth
Publicado no Biochemistry (2016)

Substrate and Cofactor Dynamics on Guanosine Monophosphate Reductase Probed by High Resolution Field Cycling (31)P NMR Relaxometry

Por Rosenberg, Masha M., Redfield, Alfred G., Roberts, Mary F., Hedstrom, Lizbeth
Publicado no J Biol Chem (2016)

Dynamic characteristics of GMP reductase complexes revealed by high resolution (31)P field cycling NMR relaxometry

Por Rosenberg, Masha M., Redfield, Alfred G., Roberts, Mary F., Hedstrom, Lizbeth
Publicado no Biochemistry (2018)

Ubiquilin-mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling

Por Coffey, Rory T., Shi, Yuntao, Long, Marcus J. C., Marr, Michael T., Hedstrom, Lizbeth
Publicado no J Biol Chem (2016)

Expression and Purification of Active Recombinant Human Alpha-1 Antitrypsin (AAT) from Escherichia coli

Por Krishnan, Beena, Hedstrom, Lizbeth, Hebert, Daniel N., Gierasch, Lila M., Gershenson, Anne
Publicado no Methods Mol Biol (2017)