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The Cys319 loop modulates the transition between dehydrogenase and hydrolase conformations in IMP dehydrogenase
X-ray crystal structures of enzyme-ligand complexes are widely believed to mimic states in the catalytic cycle, but this presumption has seldom been carefully scrutinized. In the case of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase (IMPDH), ten structures of various enzyme-subst...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3005847/ https://ncbi.nlm.nih.gov/pubmed/21062060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101590c |
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