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The antibiotic potential of prokaryotic IMP dehydrogenase inhibitors
Inosine 5′-monophosphate dehydrogenase (IMPDH) catalyzes the first committed step of guanosine 5′-monophosphate (GMP) biosynthesis, and thus regulates the guanine nucleotide pool, which in turn governs proliferation. Human IMPDHs are validated targets for immunosuppressive, antiviral and anticancer...
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| Publicado no: | Curr Med Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5036587/ https://ncbi.nlm.nih.gov/pubmed/21517780 |
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