Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity

Inosine 5′-monophosphate dehydrogenase (IMPDH) is a promising target for the treatment of Cryptosporidium infections. Here, the structure of C. parvum IMPDH (CpIMPDH) in complex with inosine 5′-monophosphate (IMP) and P131, an inhibitor with in vivo anticryptosporidial activity, is reported. P131 co...

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發表在:Acta Crystallogr F Struct Biol Commun
Main Authors: Kim, Youngchang, Makowska-Grzyska, Magdalena, Gorla, Suresh Kumar, Gollapalli, Deviprasad R., Cuny, Gregory D., Joachimiak, Andrzej, Hedstrom, Lizbeth
格式: Artigo
語言:Inglês
出版: International Union of Crystallography 2015
主題:
Molecular Parasitology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4427161/
https://ncbi.nlm.nih.gov/pubmed/25945705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X15000187
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