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Synthesis, in Vitro Evaluation and Cocrystal Structure of 4-Oxo-[1]benzopyrano[4,3-c]pyrazole Cryptosporidium parvum Inosine 5′-Monophosphate Dehydrogenase (CpIMPDH) Inhibitors
[Image: see text] Cryptosporidium inosine 5′-monophosphate dehydrogenase (CpIMPDH) has emerged as a therapeutic target for treating Cryptosporidium parasites because it catalyzes a critical step in guanine nucleotide biosynthesis. A 4-oxo-[1]benzopyrano[4,3-c]pyrazole derivative was identified as a...
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| Published in: | J Med Chem |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Chemical
Society
2014
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4281095/ https://ncbi.nlm.nih.gov/pubmed/25474504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501527z |
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