Expanding benzoxazole based inosine 5’-monophosphate dehydrogenase (IMPDH) inhibitor structure-activity as potential anti-tuberculosis agents

New drugs and molecular targets are urgently needed to address the emergence and spread of drug-resistant tuberculosis. Mycobacterium tuberculosis (Mtb) inosine 5’-monophosphate dehydrogenase 2 (MtbIMPDH2) is a promising yet controversial potential target. Inhibition of MtbIMPDH2 blocks the biosynth...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Med Chem
Prif Awduron: Chacko, Shibin, Boshoff, Helena I. M., Singh, Vinayak, Ferraris, Davide M., Gollapalli, Deviprasad R., Zhang, Minjia, Lawson, Ann P., Pepi, Michael J., Joachimiak, Andrzej, Rizzi, Menico, Mizrahi, Valerie, Cuny, Gregory D., Hedstrom, Lizbeth
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166404/
https://ncbi.nlm.nih.gov/pubmed/29746130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01839
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