Expanding benzoxazole based inosine 5’-monophosphate dehydrogenase (IMPDH) inhibitor structure-activity as potential anti-tuberculosis agents

New drugs and molecular targets are urgently needed to address the emergence and spread of drug-resistant tuberculosis. Mycobacterium tuberculosis (Mtb) inosine 5’-monophosphate dehydrogenase 2 (MtbIMPDH2) is a promising yet controversial potential target. Inhibition of MtbIMPDH2 blocks the biosynth...

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Dades bibliogràfiques
Publicat a:J Med Chem
Autors principals: Chacko, Shibin, Boshoff, Helena I. M., Singh, Vinayak, Ferraris, Davide M., Gollapalli, Deviprasad R., Zhang, Minjia, Lawson, Ann P., Pepi, Michael J., Joachimiak, Andrzej, Rizzi, Menico, Mizrahi, Valerie, Cuny, Gregory D., Hedstrom, Lizbeth
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166404/
https://ncbi.nlm.nih.gov/pubmed/29746130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01839
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