Expanding benzoxazole based inosine 5’-monophosphate dehydrogenase (IMPDH) inhibitor structure-activity as potential anti-tuberculosis agents

New drugs and molecular targets are urgently needed to address the emergence and spread of drug-resistant tuberculosis. Mycobacterium tuberculosis (Mtb) inosine 5’-monophosphate dehydrogenase 2 (MtbIMPDH2) is a promising yet controversial potential target. Inhibition of MtbIMPDH2 blocks the biosynth...

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Publicado en:J Med Chem
Main Authors: Chacko, Shibin, Boshoff, Helena I. M., Singh, Vinayak, Ferraris, Davide M., Gollapalli, Deviprasad R., Zhang, Minjia, Lawson, Ann P., Pepi, Michael J., Joachimiak, Andrzej, Rizzi, Menico, Mizrahi, Valerie, Cuny, Gregory D., Hedstrom, Lizbeth
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166404/
https://ncbi.nlm.nih.gov/pubmed/29746130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01839
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