Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds

Tuberculosis (TB) remains a worldwide problem and the need for new drugs is increasingly more urgent with the emergence of multidrug- and extensively-drug resistant TB. Inosine 5’-monophosphate dehydrogenase 2 (IMPDH2) from Mycobacterium tuberculosis (Mtb) is an attractive drug target. The enzyme ca...

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Publicado en:PLoS One
Autores principales: Makowska-Grzyska, Magdalena, Kim, Youngchang, Gorla, Suresh Kumar, Wei, Yang, Mandapati, Kavitha, Zhang, Minjia, Maltseva, Natalia, Modi, Gyan, Boshoff, Helena I., Gu, Minyi, Aldrich, Courtney, Cuny, Gregory D., Hedstrom, Lizbeth, Joachimiak, Andrzej
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594927/
https://ncbi.nlm.nih.gov/pubmed/26440283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138976
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