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Inhibition of IMPDH from Bacillus anthracis: Mechanism revealed by pre-steady state kinetics
Inosine-5′-monophosphate dehydrogenase (IMPDH) catalyzes the conversion of inosine-5′-monophosphate (IMP) to xanthosine-5′-monophosphate (XMP). The enzyme is an emerging target for antimicrobial therapy. The small molecule inhibitor A110 has been identified as potent and selective inhibitor of IMPDH...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5524190/ https://ncbi.nlm.nih.gov/pubmed/27541177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00265 |
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