Effect of Substrate on the Pre-Steady-State Kinetics of the Na(+)/Glucose Cotransporter

When measuring Na(+)/glucose cotransporter (SGLT1) activity in Xenopus oocytes with the two-electrode voltage-clamp technique, pre-steady-state currents dissipate completely in the presence of saturating α-methyl-glucose (αMG, a nonhydrolyzable glucose analog) concentrations. In sharp contrast, two...

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Bibliographic Details
Main Authors: Gagnon, Dominique G., Frindel, Carole, Lapointe, Jean-Yves
Format: Artigo
Language:Inglês
Published: Biophysical Society 2007
Subjects:
Channels, Receptors, and Electrical Signaling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751405/
https://ncbi.nlm.nih.gov/pubmed/17071656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.092296
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