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Inhibitor Mediated Protein Degradation
The discovery of drugs that cause the degradation of their target proteins has been largely serendipitous. Here we report that the tert-butyl carbamate-protected arginine (Boc(3)Arg) moiety provides a general strategy for the design of degradation-inducing inhibitors. The covalent inactivators ethac...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3361691/ https://ncbi.nlm.nih.gov/pubmed/22633414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.04.008 |
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