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The dynamic determinants of reaction specificity in the IMPDH/GMPR family of (β/α)(8) barrel enzymes
The IMPDH/GMPR family of (β/α)(8) enzymes presents an excellent opportunity to investigate how subtle changes in enzyme structure change reaction specificity. IMP dehydrogenase (IMPDH) and GMP reductase (GMPR) bind the same ligands with similar affinities and share a common set of catalytic residues...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3337344/ https://ncbi.nlm.nih.gov/pubmed/22332716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10409238.2012.656843 |
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