Evolution of Substrate Specificity within a Diverse Family of β/α-Barrel-fold Basic Amino Acid Decarboxylases: X-RAY STRUCTURE DETERMINATION OF ENZYMES WITH SPECIFICITY FOR l-ARGININE AND CARBOXYNORSPERMIDINE

Pyridoxal 5′-phosphate (PLP)-dependent basic amino acid decarboxylases from the β/α-barrel-fold class (group IV) exist in most organisms and catalyze the decarboxylation of diverse substrates, essential for polyamine and lysine biosynthesis. Herein we describe the first x-ray structure determination...

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Detalhes bibliográficos
Main Authors: Deng, Xiaoyi, Lee, Jeongmi, Michael, Anthony J., Tomchick, Diana R., Goldsmith, Elizabeth J., Phillips, Margaret A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919134/
https://ncbi.nlm.nih.gov/pubmed/20534592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.121137
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