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Directed evolution of the substrate specificity of dialkylglycine decarboxylase

Dialkylglycine decarboxylase (DGD) is an unusual pyridoxal phosphate dependent enzyme that catalyzes decarboxylation in the first and transamination in the second half-reaction of its ping-pong catalytic cycle. Directed evolution was employed to alter the substrate specificity of DGD from 2-aminoiso...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Taylor, Jared L., Price, Joseph E., Toney, Michael D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334570/
https://ncbi.nlm.nih.gov/pubmed/25500286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2014.12.003
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