Cofactor mobility determines reaction outcome in the IMPDH/GMPR (β/α)(8) barrel enzymes

IMP dehydrogenase (IMPDH) and GMP reductase (GMPR) belong to the same structural family, share a common set of catalytic residues and bind the same ligands. The structural and mechanistic features that determine reaction outcome in the IMPDH/GMPR family have not been identified. Here, we show that t...

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Bibliographic Details
Published in:Nat Chem Biol
Main Authors: Patton, Gregory C., Stenmark, Pål, Gollapalli, Deviprasad R., Sevastik, Robin, Kursula, Petri, Flodin, Susanne, Schuler, Herwig, Swales, Colin T., Eklund, Hans, Himo, Fahmi, Nordlund, Pär, Hedstrom, Lizbeth
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552316/
https://ncbi.nlm.nih.gov/pubmed/22037469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.693
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