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Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy
Cytidine triphosphate synthetase (CTPS) is a key enzyme in nucleic acid and phospholipid biosynthesis and its activity is increased in certain human cancers, making it a promising drug target. The crystal structure of the synthetase domain of human CTPS, which represents the first structure of a CTP...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
International Union of Crystallography
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2242944/ https://ncbi.nlm.nih.gov/pubmed/16820675 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309106018136 |
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