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An Improved Model of the Trypanosoma brucei CTP Synthetase Glutaminase Domain–Acivicin Complex
The natural product acivicin inhibits the glutaminase activity of cytidine triphosphate (CTP) synthetase and is a potent lead compound for drug discovery in the area of neglected tropical diseases, specifically trypanosomaisis. A 2.1‐Å‐resolution crystal structure of the acivicin adduct with the glu...
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| Pubblicato in: | ChemMedChem |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5413811/ https://ncbi.nlm.nih.gov/pubmed/28333400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700118 |
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