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Trypanosoma brucei CTP synthetase: A target for the treatment of African sleeping sickness

The drugs in clinical use against African sleeping sickness are toxic, costly, or inefficient. We show that Trypanosoma brucei, which causes this disease, has very low levels of CTP, which are due to a limited capacity for de novo synthesis and the lack of salvage pathways. The CTP synthetase inhibi...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Hofer, Anders, Steverding, Dietmar, Chabes, Andrei, Brun, Reto, Thelander, Lars
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33482/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11353848/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.111139498
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