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Trypanosoma brucei CTP synthetase: A target for the treatment of African sleeping sickness

The drugs in clinical use against African sleeping sickness are toxic, costly, or inefficient. We show that Trypanosoma brucei, which causes this disease, has very low levels of CTP, which are due to a limited capacity for de novo synthesis and the lack of salvage pathways. The CTP synthetase inhibi...

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Hlavní autoři: Hofer, Anders, Steverding, Dietmar, Chabes, Andrei, Brun, Reto, Thelander, Lars
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2001
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC33482/
https://ncbi.nlm.nih.gov/pubmed/11353848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.111139498
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