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Trypanosoma brucei CTP synthetase: A target for the treatment of African sleeping sickness

The drugs in clinical use against African sleeping sickness are toxic, costly, or inefficient. We show that Trypanosoma brucei, which causes this disease, has very low levels of CTP, which are due to a limited capacity for de novo synthesis and the lack of salvage pathways. The CTP synthetase inhibi...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Hofer, Anders, Steverding, Dietmar, Chabes, Andrei, Brun, Reto, Thelander, Lars
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33482/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11353848/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.111139498
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