Trypanosoma brucei CTP synthetase: A target for the treatment of African sleeping sickness

The drugs in clinical use against African sleeping sickness are toxic, costly, or inefficient. We show that Trypanosoma brucei, which causes this disease, has very low levels of CTP, which are due to a limited capacity for de novo synthesis and the lack of salvage pathways. The CTP synthetase inhibi...

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Detaylı Bibliyografya
Asıl Yazarlar: Hofer, Anders, Steverding, Dietmar, Chabes, Andrei, Brun, Reto, Thelander, Lars
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 2001
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC33482/
https://ncbi.nlm.nih.gov/pubmed/11353848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.111139498
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