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Trypanosoma brucei CTP synthetase: A target for the treatment of African sleeping sickness
The drugs in clinical use against African sleeping sickness are toxic, costly, or inefficient. We show that Trypanosoma brucei, which causes this disease, has very low levels of CTP, which are due to a limited capacity for de novo synthesis and the lack of salvage pathways. The CTP synthetase inhibi...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The National Academy of Sciences
2001
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC33482/ https://ncbi.nlm.nih.gov/pubmed/11353848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.111139498 |
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