Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy

Cytidine triphosphate synthetase (CTPS) is a key enzyme in nucleic acid and phospholipid biosynthesis and its activity is increased in certain human cancers, making it a promising drug target. The crystal structure of the synthetase domain of human CTPS, which represents the first structure of a CTP...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kursula, Petri, Flodin, Susanne, Ehn, Maria, Hammarström, Martin, Schüler, Herwig, Nordlund, Pär, Stenmark, Pål
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: International Union of Crystallography 2006
Gaiak:
Protein Structure Communications
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242944/
https://ncbi.nlm.nih.gov/pubmed/16820675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309106018136
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