Repurposing Cryptosporidium Inosine 5′-Monophosphate Dehydrogenase Inhibitors as Potential Antibacterial Agents

[Image: see text] Inosine 5′-monophosphate dehydrogenase (IMPDH) catalyzes the pivotal step in guanine nucleotide biosynthesis. IMPDH is a target for immunosuppressive, antiviral, and anticancer drugs, but, as of yet, has not been exploited for antimicrobial therapy. We have previously reported pote...

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Main Authors: Mandapati, Kavitha, Gorla, Suresh Kumar, House, Amanda L., McKenney, Elizabeth S., Zhang, Minjia, Rao, Suraj Nagendra, Gollapalli, Deviprasad R., Mann, Barbara J., Goldberg, Joanna B., Cuny, Gregory D., Glomski, Ian J., Hedstrom, Lizbeth
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137380/
https://ncbi.nlm.nih.gov/pubmed/25147601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500203p
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