Repurposing Cryptosporidium Inosine 5′-Monophosphate Dehydrogenase Inhibitors as Potential Antibacterial Agents

[Image: see text] Inosine 5′-monophosphate dehydrogenase (IMPDH) catalyzes the pivotal step in guanine nucleotide biosynthesis. IMPDH is a target for immunosuppressive, antiviral, and anticancer drugs, but, as of yet, has not been exploited for antimicrobial therapy. We have previously reported pote...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Mandapati, Kavitha, Gorla, Suresh Kumar, House, Amanda L., McKenney, Elizabeth S., Zhang, Minjia, Rao, Suraj Nagendra, Gollapalli, Deviprasad R., Mann, Barbara J., Goldberg, Joanna B., Cuny, Gregory D., Glomski, Ian J., Hedstrom, Lizbeth
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Chemical Society 2014
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137380/
https://ncbi.nlm.nih.gov/pubmed/25147601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500203p
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