Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism

SIRT1 is an NAD(+)-dependent deacetylase that counteracts multiple disease states associated with aging and may underlie some of the health benefits of calorie restriction. Understanding how SIRT1 is regulated in vivo could therefore lead to new strategies to treat age-related diseases. SIRT1 forms...

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Detalhes bibliográficos
Main Authors: Hubbard, Basil P, Loh, Christine, Gomes, Ana P, Li, Jun, Lu, Quinn, Doyle, Taylor LG, Disch, Jeremy S, Armour, Sean M, Ellis, James L, Vlasuk, George P, Sinclair, David A
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755073/
https://ncbi.nlm.nih.gov/pubmed/23892437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.25268
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