The Sirt1 activator SRT3025 provides atheroprotection in Apoe(−/−) mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

AIMS: The deacetylase sirtuin 1 (Sirt1) exerts beneficial effects on lipid metabolism, but its roles in plasma LDL-cholesterol regulation and atherosclerosis are controversial. Thus, we applied the pharmacological Sirt1 activator SRT3025 in a mouse model of atherosclerosis and in hepatocyte culture....

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Vydáno v:Eur Heart J
Hlavní autoři: Miranda, Melroy X., van Tits, Lambertus J., Lohmann, Christine, Arsiwala, Tasneem, Winnik, Stephan, Tailleux, Anne, Stein, Sokrates, Gomes, Ana P., Suri, Vipin, Ellis, James L., Lutz, Thomas A., Hottiger, Michael O., Sinclair, David A., Auwerx, Johan, Schoonjans, Kristina, Staels, Bart, Lüscher, Thomas F., Matter, Christian M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
FASTTrack Basic Science
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286317/
https://ncbi.nlm.nih.gov/pubmed/24603306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehu095
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