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PCSK9 Prosegment Chimera as Novel Inhibitors of LDLR Degradation

The proprotein convertase PCSK9, a target for the treatment of hypercholesterolemia, is a negative regulator of the LDL receptor (LDLR) leading to its degradation in endosomes/lysosomes and up-regulation of plasma LDL-cholesterol levels. The proprotein convertases, a family of nine secretory serine...

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Detalhes bibliográficos
Main Authors: Luna Saavedra, Yascara Grisel, Zhang, Jianbing, Seidah, Nabil G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741231/
https://ncbi.nlm.nih.gov/pubmed/23951290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072113
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