Effects of the Prosegment and pH on the Activity of PCSK9: EVIDENCE FOR ADDITIONAL PROCESSING EVENTS

PCSK9, a target for the treatment of dyslipidemia, enhances the degradation of the LDL receptor (LDLR) in endosomes/lysosomes, up-regulating LDL-cholesterol levels. Whereas the targeting and degradation of the PCSK9-LDLR complex are under scrutiny, the roles of the N- and C-terminal domains of PCSK9...

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Detalhes bibliográficos
Main Authors: Benjannet, Suzanne, Luna Saavedra, Yascara Grisel, Hamelin, Josée, Asselin, Marie-Claude, Essalmani, Rachid, Pasquato, Antonella, Lemaire, Peter, Duke, Gerald, Miao, Bowman, Duclos, Franck, Parker, Rex, Mayer, Gaétan, Seidah, Nabil G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003396/
https://ncbi.nlm.nih.gov/pubmed/20937814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.154815
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