Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other

Amyloid precursor-like protein 2 (APLP2) and sortilin were reported to individually bind the proprotein convertase subtilisin/kexin type 9 (PCSK9) and regulate its activity on the low-density lipoprotein receptor (LDLR). The data presented herein demonstrate that mRNA knockdowns of APLP2, sortilin,...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Butkinaree, Chutikarn, Canuel, Maryssa, Essalmani, Rachid, Poirier, Steve, Benjannet, Suzanne, Asselin, Marie-Claude, Roubtsova, Anna, Hamelin, Josée, Marcinkiewicz, Jadwiga, Chamberland, Ann, Guillemot, Johann, Mayer, Gaétan, Sisodia, Sangram S., Jacob, Yves, Prat, Annik, Seidah, Nabil G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Protein Synthesis and Degradation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513119/
https://ncbi.nlm.nih.gov/pubmed/26085104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.647180
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