PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice

Proprotein convertase subtilisin kexin type 9 (PCSK9), the last member of the family of Proprotein Convertases related to Subtilisin and Kexin, regulates LDL-cholesterol by promoting the endosomal/lysosomal degradation of the LDL receptor (LDLR). Herein, we show that the LDLR cell surface levels dra...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Lipid Res
Hlavní autoři: Roubtsova, Anna, Chamberland, Ann, Marcinkiewicz, Jadwiga, Essalmani, Rachid, Fazel, Ali, Bergeron, John J., Seidah, Nabil G., Prat, Annik
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2015
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617400/
https://ncbi.nlm.nih.gov/pubmed/26323289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M061952
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky