PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice

Proprotein convertase subtilisin kexin type 9 (PCSK9), the last member of the family of Proprotein Convertases related to Subtilisin and Kexin, regulates LDL-cholesterol by promoting the endosomal/lysosomal degradation of the LDL receptor (LDLR). Herein, we show that the LDLR cell surface levels dra...

Full description

Saved in:
Bibliographic Details
Published in:J Lipid Res
Main Authors: Roubtsova, Anna, Chamberland, Ann, Marcinkiewicz, Jadwiga, Essalmani, Rachid, Fazel, Ali, Bergeron, John J., Seidah, Nabil G., Prat, Annik
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2015
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617400/
https://ncbi.nlm.nih.gov/pubmed/26323289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M061952
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items