In Vivo Evidence That Furin from Hepatocytes Inactivates PCSK9

The proprotein convertase PCSK9 plays a key role in cholesterol homeostasis by binding the LDL receptor and targeting it toward degradation. PCSK9 is strongly expressed in the liver and is found in human and mouse plasma as mature (∼62 kDa) and inactivated (∼55 kDa) forms. Ex vivo data showed that h...

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Autores principales: Essalmani, Rachid, Susan-Resiga, Delia, Chamberland, Ann, Abifadel, Marianne, Creemers, John W., Boileau, Catherine, Seidah, Nabil G., Prat, Annik
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039354/
https://ncbi.nlm.nih.gov/pubmed/21147780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.192104
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