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In Vivo Evidence That Furin from Hepatocytes Inactivates PCSK9
The proprotein convertase PCSK9 plays a key role in cholesterol homeostasis by binding the LDL receptor and targeting it toward degradation. PCSK9 is strongly expressed in the liver and is found in human and mouse plasma as mature (∼62 kDa) and inactivated (∼55 kDa) forms. Ex vivo data showed that h...
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| Glavni autori: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2011
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3039354/ https://ncbi.nlm.nih.gov/pubmed/21147780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.192104 |
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