Furin Is the Primary in Vivo Convertase of Angiopoietin-like 3 and Endothelial Lipase in Hepatocytes

The proprotein convertases (PCs) furin, PC5/6, and PACE4 exhibit unique and/or complementary functions. Their knock-out (KO) in mice resulted in strong and specific phenotypes demonstrating that, in vivo, these PCs are unique and essential during development. However, they also exhibit redundant fun...

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Main Authors: Essalmani, Rachid, Susan-Resiga, Delia, Chamberland, Ann, Asselin, Marie-Claude, Canuel, Maryssa, Constam, Daniel, Creemers, John W., Day, Robert, Gauthier, Dany, Prat, Annik, Seidah, Nabil G.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Protein Synthesis and Degradation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772187/
https://ncbi.nlm.nih.gov/pubmed/23918928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.501304
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