Internalization of Proprotein Convertase PC7 from Plasma Membrane Is Mediated by a Novel Motif

Por Declercq, Jeroen, Meulemans, Sandra, Plets, Evelyn, Creemers, John W. M.
Publicado em 2012

Single Nucleotide Polymorphism (rs4932178) in the P1 Promoter of FURIN Is Not Prognostic to Colon Cancer

Por Declercq, Jeroen, Jacobs, Bart, Biesmans, Bart, Roth, Arnaud, Klingbiel, Dirk, Tejpar, Sabine, Creemers, John W.
Publicado no Biomed Res Int (2015)

PREPL deficiency with or without cystinuria causes a novel myasthenic syndrome

Por Régal, Luc, Shen, Xin-Ming, Selcen, Duygu, Verhille, Chantal, Meulemans, Sandra, Creemers, John W.M., Engel, Andrew G.
Publicado em 2014

The Dwarf Phenotype in GH240B Mice, Haploinsufficient for the Autism Candidate Gene Neurobeachin, Is Caused by Ectopic Expression of Recombinant Human Growth Hormone

Por Nuytens, Kim, Tuand, Krizia, Fu, Quili, Stijnen, Pieter, Pruniau, Vincent, Meulemans, Sandra, Vankelecom, Hugo, Creemers, John W. M.
Publicado em 2014

In Vivo Evidence That Furin from Hepatocytes Inactivates PCSK9

Por Essalmani, Rachid, Susan-Resiga, Delia, Chamberland, Ann, Abifadel, Marianne, Creemers, John W., Boileau, Catherine, Seidah, Nabil G., Prat, Annik
Publicado em 2011

The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers

Por Dahms, Sven O., Creemers, John W. M., Schaub, Yvonne, Bourenkov, Gleb P., Zögg, Thomas, Brandstetter, Hans, Than, Manuel E.
Publicado no Sci Rep (2016)

Functional and clinical relevance of novel and known PCSK1 variants for childhood obesity and glucose metabolism

Por Löffler, Dennis, Behrendt, Susanne, Creemers, John W.M., Klammt, Jürgen, Aust, Gabriela, Stanik, Juraj, Kiess, Wieland, Kovacs, Peter, Körner, Antje
Publicado no Mol Metab (2016)

Phlorizin Pretreatment Reduces Acute Renal Toxicity in a Mouse Model for Diabetic Nephropathy

Por Brouwers, Bas, Pruniau, Vincent P. E. G., Cauwelier, Elisa J. G., Schuit, Frans, Lerut, Evelyne, Ectors, Nadine, Declercq, Jeroen, Creemers, John W. M.
Publicado em 2013

The Paired Basic Amino Acid-cleaving Enzyme 4 (PACE4) Is Involved in the Maturation of Insulin Receptor Isoform B: AN OPPORTUNITY TO REDUCE THE SPECIFIC INSULIN RECEPTOR-DEPENDENT...

Por Kara, Imène, Poggi, Marjorie, Bonardo, Bernadette, Govers, Roland, Landrier, Jean-François, Tian, Sun, Leibiger, Ingo, Day, Robert, Creemers, John W. M., Peiretti, Franck
Publicado no J Biol Chem (2015)

Proprotein convertase furin regulates osteocalcin and bone endocrine function

Por Al Rifai, Omar, Chow, Jacqueline, Lacombe, Julie, Julien, Catherine, Faubert, Denis, Susan-Resiga, Delia, Essalmani, Rachid, Creemers, John W.M., Seidah, Nabil G., Ferron, Mathieu
Publicado no J Clin Invest (2017)

Loss of Endothelial Furin Leads to Cardiac Malformation and Early Postnatal Death

Por Kim, WooJin, Essalmani, Rachid, Szumska, Dorota, Creemers, John W. M., Roebroek, Anton J. M., D'Orleans-Juste, Pedro, Bhattacharya, Shoumo, Seidah, Nabil G., Prat, Annik
Publicado em 2012

Furin Is the Primary in Vivo Convertase of Angiopoietin-like 3 and Endothelial Lipase in Hepatocytes

Por Essalmani, Rachid, Susan-Resiga, Delia, Chamberland, Ann, Asselin, Marie-Claude, Canuel, Maryssa, Constam, Daniel, Creemers, John W., Day, Robert, Gauthier, Dany, Prat, Annik, Seidah, Nabil G.
Publicado em 2013

Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth

Por Declercq, Jeroen, Brouwers, Bas, Pruniau, Vincent P. E. G., Stijnen, Pieter, Tuand, Krizia, Meulemans, Sandra, Prat, Annik, Seidah, Nabil G., Khatib, Abdel-Majid, Creemers, John W. M.
Publicado no Biomed Res Int (2015)

Deletion of PREPL, a Gene Encoding a Putative Serine Oligopeptidase, in Patients with Hypotonia-Cystinuria Syndrome

Por Jaeken, Jaak, Martens, Kevin, François, Inge, Eyskens, François, Lecointre, Claudine, Derua, Rita, Meulemans, Sandra, Slootstra, Jerry W., Waelkens, Etienne, Zegher, Francis de, Creemers, John W. M., Matthijs, Gert
Publicado em 2006

Metabolic and Behavioural Phenotypes in Nestin-Cre Mice Are Caused by Hypothalamic Expression of Human Growth Hormone

Por Declercq, Jeroen, Brouwers, Bas, Pruniau, Vincent P. E. G., Stijnen, Pieter, de Faudeur, Geoffroy, Tuand, Krizia, Meulemans, Sandra, Serneels, Lutgarde, Schraenen, Anica, Schuit, Frans, Creemers, John W. M.
Publicado no PLoS One (2015)

Role of furin in granular acidification in the endocrine pancreas: Identification of the V-ATPase subunit Ac45 as a candidate substrate

Por Louagie, Els, Taylor, Neil A., Flamez, Daisy, Roebroek, Anton J. M., Bright, Nicholas A., Meulemans, Sandra, Quintens, Roel, Herrera, Pedro L., Schuit, Frans, Van de Ven, Wim J. M., Creemers, John W. M.
Publicado em 2008

Generation and characterization of non-competitive furin-inhibiting nanobodies

Por Zhu, Jingjing, Declercq, Jeroen, Roucourt, Bart, Ghassabeh, Gholamreza H., Meulemans, Sandra, Kinne, Jörg, David, Guido, Vermorken, Alphons J. M., Van de Ven, Wim J. M., Lindberg, Iris, Muyldermans, Serge, Creemers, John W. M.
Publicado no Biochem J (2012)

Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity

Por Creemers, John W.M., Choquet, Hélène, Stijnen, Pieter, Vatin, Vincent, Pigeyre, Marie, Beckers, Sigri, Meulemans, Sandra, Than, Manuel E., Yengo, Loïc, Tauber, Maithé, Balkau, Beverley, Elliott, Paul, Jarvelin, Marjo-Riitta, Van Hul, Wim, Van Gaal, Luc, Horber, Fritz, Pattou, François, Froguel, Philippe, Meyre, David
Publicado em 2012

Impaired Islet Function in Commonly Used Transgenic Mouse Lines due to Human Growth Hormone Minigene Expression

Por Brouwers, Bas, de Faudeur, Geoffroy, Osipovich, Anna B., Goyvaerts, Lotte, Lemaire, Katleen, Boesmans, Leen, Cauwelier, Elisa J.G., Granvik, Mikaela, Pruniau, Vincent P.E.G., Van Lommel, Leentje, Van Schoors, Jolien, Stancill, Jennifer S., Smolders, Ilse, Goffin, Vincent, Binart, Nadine, Veld, Peter in’t, Declercq, Jeroen, Magnuson, Mark A., Creemers, John W.M., Schuit, Frans, Schraenen, Anica
Publicado no Cell Metab (2014)

Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency

Por Jackson, Robert S., Creemers, John W.M., Farooqi, I. Sadaf, Raffin-Sanson, Marie-Laure, Varro, Andrea, Dockray, Graham J., Holst, Jens J., Brubaker, Patricia L., Corvol, Pierre, Polonsky, Kenneth S., Ostrega, Diane, Becker, Kenneth L., Bertagna, Xavier, Hutton, John C., White, Anne, Dattani, Mehul T., Hussain, Khalid, Middleton, Stephen J., Nicole, Thomasina M., Milla, Peter J., Lindley, Keith J., O’Rahilly, Stephen
Publicado em 2003