Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth

Proprotein convertases are subtilisin-like serine endoproteases that cleave and hence activate a variety of proproteins, including growth factors, receptors, metalloproteases, and extracellular matrix proteins. Therefore, it has been suggested that inhibition of the ubiquitously expressed proprotein...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Declercq, Jeroen, Brouwers, Bas, Pruniau, Vincent P. E. G., Stijnen, Pieter, Tuand, Krizia, Meulemans, Sandra, Prat, Annik, Seidah, Nabil G., Khatib, Abdel-Majid, Creemers, John W. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4475760/
https://ncbi.nlm.nih.gov/pubmed/26167473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/148651
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