The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis

The secretory factor VEGF-C has been directly implicated in various physiological processes during embryogenesis and human cancers. However, the importance of the conversion of its precursor proVEGF-C to mature VEGF-C in tumorigenesis, and vessel formation and the identity of the protease(s) that re...

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Bibliographic Details
Main Authors: Siegfried, Geraldine, Basak, Ajoy, Cromlish, James A., Benjannet, Suzanne, Marcinkiewicz, Jadwiga, Chrétien, Michel, Seidah, Nabil G., Khatib, Abdel-Majid
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2003
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC156106/
https://ncbi.nlm.nih.gov/pubmed/12782675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317220
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