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The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers
Proprotein Convertases (PCs) represent highly selective serine proteases that activate their substrates upon proteolytic cleavage. Their inhibition is a promising strategy for the treatment of cancer and infectious diseases. Inhibitory camelid antibodies were developed, targeting the prototypical PC...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5037460/ https://ncbi.nlm.nih.gov/pubmed/27670069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34303 |
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