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X-ray Structures of Human Furin in Complex with Competitive Inhibitors

[Image: see text] Furin inhibitors are promising therapeutics for the treatment of cancer and numerous infections caused by bacteria and viruses, including the highly lethal Bacillus anthracis or the pandemic influenza virus. Development and improvement of inhibitors for pharmacological use require...

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Autors principals: Dahms, Sven O., Hardes, Kornelia, Becker, Gero L., Steinmetzer, Torsten, Brandstetter, Hans, Than, Manuel E.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026159/
https://ncbi.nlm.nih.gov/pubmed/24666235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500087x
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